Introducing
Dr Charles Malpas
Hello, I’m Charles, a Research Fellow and Research Stream Leader for Neurocognitive disorders and Epilepsy.
Dr Charles Malpas
Research Stream Leader (Neurocognitive Disorders & Epilepsy)
MPsych(ClinNeuro), Ph.D.(ClinNeuro), GradCertAppStats, GradCertUniTeach, MAPS, FCCN, CPsychol(UK), AFBPsP
a little bit about me
I am a research fellow in the Clinical Outcomes Research Unit (CORe) at the Department of Medicine, Royal Melbourne Hospital. My research at CORe covers the neurocognitive disorders and epilepsy, and involves the application of advanced statistical modelling to answer clinically relevant questions. I am particularly interested in the application of Bayesian methods to predict clinical outcomes.
I completed a postdoctoral fellowship in neuroimaging at the Murdoch Children’s Research Institute (MCRI), where I was supported by an NHMRC Peter Doherty Australian Biomedical Fellowship. Clinically, I am a board-endorsed neuropsychologist (MAPS FCCN), currently working in the Comprehensive Epilepsy Program at The Alfred Hospital and in private practice. I am also a chartered psychologist in the UK (CPsychol) and Associate Fellow of the British Psychological Society (AFBPsP).
Publications
- Early clinical markers of aggressive multiple sclerosis.
- Factors associated with subjective cognitive function in epilepsy and psychogenic non-epileptic seizures.
- The histopathological staging of tau, but not amyloid, corresponds to antemortem cognitive status, dementia stage, functional abilities, and neuropsychiatric symptoms.
- Timing of high-efficacy therapy for multiple sclerosis: a retrospective observational cohort study.
- Head Motion During MRI Predicted by out-of-Scanner Sustained Attention Performance in Attention-Deficit/Hyperactivity Disorder.
- Antiepileptic drugs are not independently associated with cognitive dysfunction.
- Clinical and therapeutic predictors of disease outcomes in AQP4-IgG+ neuromyelitis optica spectrum disorder.
- Psychometric properties of the Hospital Anxiety and Depression Scale in an inpatient video-monitoring epilepsy cohort.
- Optic Radiation Tractography in Pediatric Brain Surgery Applications: A Reliability and Agreement Assessment of the Tractography Method.
- Distinct psychopathology profiles in patients with epileptic seizures compared to non-epileptic psychogenic seizures.
- Abbreviated assessment of psychopathology in patients with suspected seizure disorders.
- Personality profiles differ between patients with epileptic seizures and patients with psychogenic non-epileptic seizures.
- A pilot study of the utility of cerebrospinal fluid neurofilament light chain in differentiating neurodegenerative from psychiatric disorders: A 'C-reactive protein' for psychiatrists and neurologists?
- Resting-state functional connectivity, cognition, and fatigue in response to cognitive exertion: a novel study in adolescents with chronic fatigue syndrome.
- Brain Imaging of the Cortex in ADHD: A Coordinated Analysis of Large-Scale Clinical and Population-Based Samples.
- A network analysis approach to ADHD symptoms: More than the sum of its parts.
- Metabolic patterns and seizure outcomes following anterior temporal lobectomy.
- MRI correlates of general intelligence in neurotypical adults.
- Tau and Amyloid-β Cerebrospinal Fluid Biomarkers have Differential Relationships with Cognition in Mild Cognitive Impairment.
- Short-term white matter alterations in Alzheimer's disease characterized by diffusion tensor imaging.
- Contralesional thalamic surface atrophy and functional disconnection 3 months after ischemic stroke.
- Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration.
- Longitudinal Partial Volume Correction in 2-[18F]-Fluoro-2-Deoxy-D-Glucose Positron Emission Tomography Studies of Alzheimer Disease.
- White matter alterations at pubertal onset.
- Cerebrospinal Fluid Biomarkers are Differentially Related to Structural and Functional Changes in Dementia of the Alzheimer's Type.
- Multimodal Structural Neuroimaging Markers of Brain Development and ADHD Symptoms.
- A Phase IIa Randomized Control Trial of VEL015 (Sodium Selenate) in Mild-Moderate Alzheimer's Disease.
- Recovery of White Matter following Pediatric Traumatic Brain Injury Depends on Injury Severity.
- Cortical morphometry in attention deficit/hyperactivity disorder: Contribution of thickness and surface area to volume.
- Structural neuroimaging correlates of cognitive status in older adults: A person-oriented approach.
- Differential Functional Connectivity Correlates of Cerebrospinal Fluid Biomarkers in Dementia of the Alzheimer's Type.
- Developmental brain trajectories in children with ADHD and controls: a longitudinal neuroimaging study.
- The effect of single-dose methylphenidate on resting-state network functional connectivity in ADHD.
- Neurite density index is sensitive to age related differences in the developing brain.
- Development of white matter fibre density and morphology over childhood: A longitudinal fixel-based analysis.
- Supranutritional Sodium Selenate Supplementation Delivers Selenium to the Central Nervous System: Results from a Randomized Controlled Pilot Trial in Alzheimer's Disease.
- Different brain networks underlying intelligence in autism spectrum disorders.
- Age, sex, and puberty related development of the corpus callosum: a multi-technique diffusion MRI study.